We can also become behaviorally addicted to gambling, sex, masturbation, or shopping. Compulsive use of any substance would be an example of having an unhealthy relationship with the substance. Certain drugs or medications may also interact negatively with 2C-B. One of the main benefits of 2C-B over MDMA is that users usually don’t experience difficulty falling asleep after the experience. The intensity of effects from 2CB increases steadily along with the dose. When various government regulators started banning 2C-B, they did so by banning the entire 2C-x family — as defined by the chemical structure above.

It’s not clear whether or not microdoses of 2C-B are safe long term. There have been reports of 2C-B triggering a false-positive on amphetamine tests, but this is very rare. 2C-B has also been shown to have some action at the alpha-adrenergic receptors 3. This is likely one of the main mechanisms involved with the substance’s stimulating effects. As described above, behavioral addiction is the type of addiction we can have for the way a substance or activity makes us feel. Our body isn’t dependent on the substance, but we still seek it out in order to feel a certain way.

They are not the type of drugs on which people are likely to become physically dependent. The drug is usually taken orally, but can also be taken by rectal or intravenous administration, insufflated or vaporised 4. Other ways of taking drugs, such as by smoking, appear to be less common 3. There is no current data for the LD50 of 2C-B, but it is thought to be considerably higher than the active dose.

Single Dose of Psilocybin Yields Long-Term Depression Remission in Over 50% of Cancer Patients

Selective Serotonin Reuptake Inhibitors (SSRIs) and Monoamine Oxidase Inhibitors (MAOIs) can interact with serotonergic psychedelics. Combining them can lead to serotonin syndrome, a potentially life-threatening condition. We’re running a continual survey on the use of 2C-B to better understand the effects and use patterns surrounding this unique psychedelic substance. Compared to other 2C-x drugs, 2C-B is the second most potent agonist of serotonin receptors only to 2C-I.

Following the ban, other phenethylamines were sold in place of 2C-B until the Netherlands became the first country in the world to ban 2C-I, 2C-T-2 and 2C-T-7 alongside 2C-B. In Belgium, 2C-B is a controlled substance making production, distribution, and possession illegal. 2C-B is controlled in Australia and on the list of substances subject to import and export controls (Appendix B). It was placed on Schedule One of the Drugs Misuse and Trafficking Act when it first came to notice in 1994, when in a showcase legal battle chemist R. Alexander Shulgin came to Australia to testify on behalf of the defense, to no avail.

Take Your Time:

In addition, the amount in a single capsule or tablet can vary significantly. Interestingly though, the most common report is that there is practically no next-day comedown or hangover and that the whole experience is much more gentle than its cousins MDMA and LSD. “LSD-like visuals but without the ‘head games’ that sometimes comes with traditional psychedelics,” is how Raquel described it. Plus, many say they don’t feel the “serotonin dump” or depressive come-down that can follow an MDMA experience.

  • This means a small increase in dose will produce a large increase in effects.
  • We recognise the continued connection of First Nations people to the land, the waterways and to community and kin, and pay respects to Elders past and present.
  • 2C-B is still considered by many to be the best psychedelic to use during sex of all time.
  • Everybody should test their drugs before using them to avoid mistakenly consuming toxic alternatives.
  • Samples of 2C-B have been shown to contain substances such as methamphetamines, MDA, PMA, PMMA, NBOMe, or various opiates.

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  • However, as with all psychedelics, your experience may differ from that of others.
  • DoubleBlind Magazine does not encourage or condone any illegal activities, including but not limited to the use of illegal substances.
  • Due to the illegal or controlled nature of these drugs, it is not advised that you attempt to purchase, source, or otherwise possess any Scheduled substances, as you may be at risk of civil and criminal penalties.
  • According to PiHKAL, 2C-B lasts between four and eight hours, and that’s pretty in line with what the 31 people who took my survey reported.
  • A single 25mg dose of psilocybin paired with psychological support has resulted in 57% of patients.

For a ‘2C’ drug to be illegal it must fulfil the criteria set out by the generic definition for the phenethylamine family of drugs. 2C drugs are normally sold as pills or powders, usually a white powder, but this could vary. For example, 2CB and 2CT-7 have been sold as white powders or tiny 5mg pills. However, taking it with other drugs can significantly increase the risk of overdose.

Due to the heavily restricted status of this substance, it’s unlikely we’re going to see this research anytime in the near future. Most people suggest the effects of 2C-B are a combination of LSD and MDMA. However, it’s more accurate to suggest the effects of 2C-B resemble mescaline 2cb psychedelic — which is actually the molecule used as inspiration for creating the entire 2C class of drugs, to begin with.

Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats. Anecdotal evidence suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses or using it very sparingly (although nothing can be completely guaranteed). In the United States, it gained popularity as an alternative to MDMA after the latter was classified as a Schedule I substance in 1985.

Multi-sensory effects

A better comparison is mescaline — which is the molecule Alexander Shulgin used to derive the 2C class of drugs, to begin with. 2C-B is one of the most popular psychoactive substances globally — despite there being virtually no research available on its safety or effect profiles in the medical literature. 2C-B and related phenethylamines like mescaline have a much weaker action on this receptor. This suggests there are other mechanisms involved with the drug’s hallucinogenic effects.

On a Saturday night in a north London club, 26-year-old Mo swallows a pink pill with a mouthful of Red Bull. Third Wave’s mission is to nurture the emerging psychedelic ecosystem by providing individuals with research-based education, access to vetted providers, and membership in our global community of psychedelic pioneers. At this time, it’s unclear whether it’s worthwhile to microdose with 2C-B. Third Wave’s Ultimate Guide to Sourcing Psychedelic Medicine offers step-by-step instructions for navigating the dark web and recommendations for lesser-known (legal) psychedelic alternatives with similar effects. One mother who took the drug with her son—who had recently moved away—learned how to let go as a parent and accept his individuality. Importantly for their relationship, she came to appreciate him as a separate, self-contained being.37 Others report its usefulness in strengthening bonds between couples.

It’s not uncommon for people using 2C-B to come to some sort of “realization” about their life. This realization may remain after the trip, but it may also be forgotten. Some could even describe the visuals at higher doses to be “cartoon-like” — which is similar to the visuals experienced with higher doses of mescaline. Lower doses of around 5 mg have effects most similar to MDMA or Adderall, while the higher doses (more than 15 mg) offer formidable hallucinogenic effects comparable to LSD, psilocybin, or mescaline. The qualities of 2C-B made it popular as a sex-enhancement drug in the 80s.

Alexander Shulgin reported a 100 mg oral dose taken without apparent harm 9, 4. There is not much information regarding the pharmacological action of 2C-B and other 2C hallucinogenic drugs despite first being synthesised many years ago. If your use of 2C-B is affecting your health, family, relationships, work, school, financial or other life situations, or you’re concerned about someone else, you can find help and support. The effects of taking 2C-B with other drugs − including over-the-counter or prescribed medications − can be unpredictable and dangerous. When it was first used within the psychiatric community, 2C-B was sold as a sexual enhancer.

2C-B is not known to be physically addictive, but like all such substances a user can develop a psychological dependence (feeling like they need to keep taking it). A short term tolerance can build up if it is used for two or more days in a row, but this will reduce fairly quickly. If you’re a regular user, it’s therefore advisable to have a break of a few days each week, or longer if you start to notice any side-effects or that the drug is no longer taking effect. Some evidence suggests that the hallucinogenic effects of the 2C compounds are produced through binding with a different type of serotonin receptor, though this is yet to be confirmed 1. In common with other hallucinogenic drugs, 2C-B and other 2C drugs bind to a specific type of serotonin receptor.

However, as with all psychedelics, your experience may differ from that of others. Some users might find the stimulating effects to verge on restlessness or overstimulation. Most psychedelics work by activating the 5-HT2A serotonin receptors.